Both Kit Harington and Jon Snow of Game of Thrones possess a resolve within them that allows them to shine through any limitations that are placed upon them.
The reason Ryan Reynolds could accomplish so much is because he was unwilling to succumb to mediocrity. He used his insecurities as a tool to use in acting.
Logic is a great example of an artist with a message. Rather than let the darkness in his life weigh him down, he used negativity to create something positive.